Document and Entity Information Statement [Table] Statement [Line Items] Statement Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Public Float Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Period Focus CONSOLIDATED BALANCE SHEETS Assets [Abstract] ASSETS Assets, Current [Abstract] Current Assets: Cash and Cash Equivalents, at Carrying Value Cash and Cash Equivalents at End of Period Cash and Cash Equivalents at Beginning of Period Cash and Cash Equivalents Available-for-sale Securities, Debt Securities, Current Marketable Securities Fair Value Accounts and Other Receivables, Net, Current Accounts and Other Receivables Prepaid Expense and Other Assets, Current Prepaid and Other Current Assets Assets, Current Total Current Assets Property and Equipment,Net Property and Equipment, Net Property and Equipment, Net Intangible Assets, Net (Excluding Goodwill) Intangible Assets, Net Intangible Assets, Net (Excluding Goodwill) Other Assets, Noncurrent Other Assets Other assets Goodwill Goodwill Assets Total Assets Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities, Current [Abstract] Current Liabilities: Accounts Payable, Current Accounts Payable Accrued Expenses Accrued Expenses Accrued Expenses Other Liabilities, Current Less Current Portion Current Portion of Long-Term Liabilities Liabilities, Current Total Current Liabilities Other Liabilities, Noncurrent Other Long-Term Liabilities Long-Term Portion Liabilities Total Liabilities Commitments and Contingencies. Commitments and Contingent Liabilities (Notes 14 and 16) Stockholders' Equity Attributable to Parent [Abstract] Stockholders' Equity: Preferred Stock, Value, Issued Convertible Preferred Stock, $.01 Par Value; 3,000,000 Shares Authorized; No Shares Issued and Outstanding at December 31, 2014 and 2013 Common Stock, Value, Issued Common Stock, $.001 Par Value; 297,000,000 Shares Authorized; 89,592,779 and 89,246,832 Shares Issued and Outstanding at December 31, 2014 and 2013, respectively Additional Paid in Capital, Common Stock Additional Paid-In Capital Accumulated Other Comprehensive Income (Loss), Net of Tax Balance at the end of the period Balance at the beginning of the period Accumulated Other Comprehensive Income Retained Earnings (Accumulated Deficit) Accumulated Deficit Balance Balance Balance Total Stockholders' Equity Liabilities and Equity Total Liabilities and Stockholders' Equity Preferred Stock, Par or Stated Value Per Share Convertible Preferred Stock, Par Value (in dollars per share) Preferred stock, shares authorized Convertible Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Convertible Preferred Stock, Shares Issued Preferred Stock, Shares Outstanding Convertible Preferred Stock, Shares Outstanding Common Stock, Par or Stated Value Per Share Common Stock, Par Value (in dollars per share) Common Stock, Shares Authorized Common Stock, Shares Authorized Balance. Balance (in shares) Balance (in shares) Common Stock, Shares Issued Shares common stock issued in connection with supply agreement Common Stock, Shares, Outstanding Common Stock, Shares Outstanding CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Revenues [Abstract] REVENUE: This element represents revenue from product development and licensing agreements. Revenue from Product Development and Licensing Agreements Product Development and Licensing Agreements This element represents revenue earned during the period arising from products sold or services provided under the terms of a contract. Also include revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements. Revenue from Contracts and Grants Contracts and Grants Royalty Revenue Product Royalties Revenues Total revenue Total Revenue Costs and Expenses [Abstract] OPERATING EXPENSE: Research and Development Expense Research and Development Research and Development expense Product royalty expense Royalty General and Administrative Expense General and Administrative Amortization expense Amortization expense for intangible assets Amortization of Acquired Intangible Assets Amortization of Intangible Assets Costs and Expenses Total Operating Expense Operating Income (Loss) Operating Loss Interest and Other Income Investment and Other Income, Net Interest Expense Interest Expense Net Loss Pre-tax loss Net Loss Net Loss Earnings Per Share, Basic and Diluted Basic and Diluted Net Loss Per Common Share (in dollars per share) Basic and diluted net loss per common share (in dollars per share) Weighted Average Number of Shares Outstanding, Basic and Diluted Shares Used in Calculating Basic and Diluted Net Loss per Share (in shares) COMPREHENSIVE LOSS COMPREHENSIVE LOSS: Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other Comprehensive Income (Loss): Foreign Currency Translation Adjustments Net Foreign Currency Translation Adjustments Unrealized Gain (Loss) on Marketable Securities Unrealized Gains (Losses) on Marketable Securities Unrealized (Loss) Gain on Marketable Securities Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive Loss CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock [Member] Common Stock Additional Paid In Capital [Member] Additional Paid-In Capital Accumulated Other Comprehensive Income [Member] Accumulated Other Comprehensive Income Retained Earnings [Member] Accumulated Deficit Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Stock Issued During Period, Value, Employee Stock Purchase Plan Shares Issued under Stock Option and Employee Stock Purchase Plans Stock Issued During Period, Shares, Employee Stock Purchase Plans Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) Shares issued under the plan Shares Issued In Connection With Cantor Agreement Shares Issued in Connection with Cantor Agreement Stock Issued During Period, Shares, Other Shares Issued in Connection with Cantor Agreement (in shares) Shares issued for services Shares Issued in Connection with Supply Agreement Stock Issued In Connection With Supply Agreement Shares Shares Issued in Connection with Supply Agreement (in shares) Shares Issued in Underwritten Offering Net proceeds from sale of stock in an underwritten public offering Shares Issued in Underwritten Offering (in shares) Common stock issued (in shares) Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Share-Based Compensation CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Cash Flows from Operating Activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to Reconcile Net Loss to Net Cash Used in Operating Activities: Depreciation and amortization expense Depreciation and Amortization Depreciation and amortization expense Accretion (Amortization) of Discounts and Premiums, Investments Amortization and Premium of Marketable Securities Realized (Gain) Loss on Sales and Maturities of Marketable Securities Realized Gain on Sales and Maturities of Marketable Securities Gain (Loss) on Disposition of Property Plant Equipment Loss (Gain) on Sale or Disposal of Assets Share-based Compensation Stock-Based Compensation Expense Amortization of Debt Discount (Premium) Non Cash Expense Increase (Decrease) in Operating Capital [Abstract] Changes in Operating Assets and Liabilities: Increase (Decrease) in Accounts and Other Receivables Accounts and Other Receivables Increase (Decrease) in Prepaid Expense and Other Assets Prepaid and Other Current Assets Increase (Decrease) in Other Operating Assets Other Assets Increase (Decrease) in Accounts Payable and Accrued Liabilities Accounts Payable and Accrued Expenses Increase (Decrease) in Other Operating Liabilities Other Liabilities Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operations Net Cash Used in Operating Activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Cash Flows From Investing Activities: Proceeds from Sale and Maturity of Marketable Securities Sales and Maturities of Marketable Securities Payments to Acquire Marketable Securities Purchases of Marketable Securities Payments to Acquire Property, Plant, and Equipment Acquisition of Property and Equipment Proceeds from Sale of Productive Assets Proceeds from Sale or Disposal of Assets Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net Cash Used in Investing Activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Cash Flows From Financing Activities: Proceeds from Issuance of Common Stock Net proceeds from sale of common stock Net Proceeds from Stock Issuances Proceeds from Stock Plans Proceeds from Issuance of Stock from Employee Benefit Plans Repayments of Secured Debt Payments of Term Loan Repayments of Other Long-term Debt Payments of Other Liabilities Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net Cash Provided by Financing Activities Effect of Exchange Rate on Cash and Cash Equivalents, Continuing Operations Effect of Exchange Rate Changes on Cash and Cash Equivalents Net Cash Provided by (Used in) Continuing Operations Net Increase (Decrease) in Cash and Cash Equivalents Supplemental Cash Flow Information [Abstract] Supplemental Disclosure of Cash Flow Information Interest Paid Cash Paid for Interest Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Non-cash Investing Activities Construction in Progress Expenditures Incurred but Not yet Paid Accrued construction in progress NATURE OF BUSINESS AND OVERVIEW Basis of Accounting [Text Block] NATURE OF BUSINESS AND OVERVIEW SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Significant Accounting Policies [Text Block] SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Comprehensive Income (Loss) Note [Text Block] COMPREHENSIVE LOSS FAIR VALUE MEASUREMENTS. Fair Value Disclosures [Text Block] FAIR VALUE MEASUREMENTS MARKETABLE SECURITIES Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] MARKETABLE SECURITIES PROPERTY AND EQUIPMENT, NET Property, Plant and Equipment Disclosure [Text Block] PROPERTY AND EQUIPMENT, NET INTANGIBLE ASSETS AND GOODWILL Goodwill and Intangible Assets Disclosure [Text Block] INTANGIBLE ASSETS AND GOODWILL ACCRUED EXPENSES. Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] ACCRUED EXPENSES OTHER LONG-TERM LIABILITIES Other Liabilities Disclosure [Text Block] OTHER LONG-TERM LIABILITIES TERM LOAN. Long-term Debt [Text Block] TERM LOAN STOCKHOLDERS' EQUITY Stockholders' Equity Note Disclosure [Text Block] STOCKHOLDERS' EQUITY STOCK-BASED COMPENSATION Disclosure of Compensation Related Costs, Share-based Payments [Text Block] STOCK-BASED COMPENSATION REVENUE. This element may be used to capture the complete disclosure pertaining to an entity's significant revenue contracts and arrangements. Significant Revenue Arrangements Disclosure [Text Block] REVENUE COLLABORATION AGREEMENTS Collaborative Arrangement Disclosure [Text Block] COLLABORATION AGREEMENTS INCOME TAXES Income Tax Disclosure [Text Block] INCOME TAXES COMMITMENTS AND CONTINGENCIES Commitments and Contingencies Disclosure [Text Block] COMMITMENTS AND CONTINGENCIES RETIREMENT SAVINGS PLAN Pension and Other Postretirement Benefits Disclosure [Text Block] RETIREMENT SAVINGS PLAN SELECTED QUARTERLY FINANCIAL DATA (Unaudited) Quarterly Financial Information [Text Block] SELECTED QUARTERLY FINANCIAL DATA (Unaudited) Basis of Accounting, Policy [Policy Text Block] Basis of Presentation Use of Estimates, Policy [Policy Text Block] Use of Estimates Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Marketable Securities, Policy [Policy Text Block] Marketable Securities Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk and of Significant Customers and Suppliers Fair Value Measurement, Policy [Policy Text Block] Fair Value Measurements Property, Plant and Equipment, Policy [Policy Text Block] Property and Equipment Business Combinations Policy [Policy Text Block] Business Combinations Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block] Intangible Assets Goodwill and Intangible Assets, Goodwill, Policy [Policy Text Block] Goodwill Impairment or Disposal of Long-Lived Assets, Including Intangible Assets, Policy [Policy Text Block] Impairment of Long-Lived Assets Revenue Recognition, Policy [Policy Text Block] Revenue Recognition Research and Development Expense, Policy [Policy Text Block] Research and Development Expenses Disclosure of accounting policy for patent costs. Patent Costs Policy [Text Block] Patent Costs Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Stock-Based Compensation Foreign Currency Transactions and Translations Policy [Policy Text Block] Foreign Currency Translation Income Tax, Policy [Policy Text Block] Income Taxes Comprehensive Income, Policy [Policy Text Block] Comprehensive Loss Earnings Per Share, Policy [Policy Text Block] Net Loss Per Share New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Schedule of potentially dilutive common that have not been included in the net loss per common share calculations because the effect would have been anti-dilutive Schedule of potentially dilutive common shares that have not been included in the net loss per common share calculations because the effect would have been anti-dilutive Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] Summary of changes in accumulated other comprehensive income (loss) by component Fair Value, Assets Measured on Recurring Basis [Table Text Block] Schedule of financial assets subject to fair value measurements Schedule of Available-for-sale Securities Reconciliation [Table Text Block] Summary of marketable securities Property, Plant and Equipment [Table Text Block] Schedule of property and equipment Schedule of Intangible Assets and Goodwill [Table Text Block] Schedule of intangible assets, net of accumulated amortization, and goodwill Schedule of Accrued Liabilities [Table Text Block] Schedule of accrued expenses Tabular disclosure of other long-term liabilities, not separately disclosed on the balance sheet. Schedule of Other Long Term Liabilities [Table Text Block] Schedule of Other long-term liabilities Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] Summary of stock option activity Schedule of Nonvested Share Activity [Table Text Block] Summary of restricted stock activity Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Schedule of stock-based compensation expense Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of assumptions used for the fair values of employee stock options granted Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Schedule of components of income tax expense attributable to continuing operations