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        <link:definition>1040 - Disclosure - FAIR VALUE MEASUREMENTS</link:definition>
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        <link:definition>1070 - Disclosure - INTANGIBLE ASSETS AND GOODWILL</link:definition>
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        <link:definition>1110 - Disclosure - STOCKHOLDERS' EQUITY</link:definition>
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        <link:definition>0030 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY</link:definition>
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        <link:definition>1180 - Disclosure - SELECTED QUARTERLY FINANCIAL DATA (Unaudited)</link:definition>
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        <link:definition>1170 - Disclosure - RETIREMENT SAVINGS PLAN</link:definition>
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        <link:definition>1160 - Disclosure - COMMITMENTS AND CONTINGENCIES</link:definition>
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        <link:definition>1140 - Disclosure - COLLABORATION AGREEMENTS</link:definition>
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        <link:definition>1080 - Disclosure - ACCRUED EXPENSES</link:definition>
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        <link:definition>0021 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS CALC 2</link:definition>
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