99900 - Disclosure - Standard And Custom Axis Domain Defaults link:presentationLink link:calculationLink link:definitionLink 00100 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 00200 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 00400 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 40401 - Disclosure - Fair Value Measurements (Details) link:presentationLink link:calculationLink link:definitionLink 40501 - Disclosure - Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 40601 - Disclosure - Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 40702 - Disclosure - Leases - Future minimum lease payments under non-cancellable leases (Details) link:presentationLink link:calculationLink link:definitionLink 40702 - Disclosure - Leases - Future minimum lease payments under non-cancellable leases (Details) (Calc 2) link:presentationLink link:calculationLink link:definitionLink 40901 - Disclosure - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 41001 - Disclosure - Other Long-Term Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 41501 - Disclosure - Income Taxes - Summary (Details) Calc2 link:presentationLink link:calculationLink link:definitionLink 41502 - Disclosure - Income Taxes - Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 41503 - Disclosure - Income Taxes - Summary of deferred tax assets and liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 00090 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 00105 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 00300 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 40202 - Disclosure - Summary of Significant Accounting Policies - Concentration of Credit Risk and Significant Customers and Suppliers (Details) link:presentationLink link:calculationLink link:definitionLink 40203 - Disclosure - Summary of Significant Accounting Policies - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 40204 - Disclosure - Summary of Significant Accounting Policies - Leases (Details) link:presentationLink link:calculationLink link:definitionLink 40206 - Disclosure - Summary of Significant Accounting Policies - Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 40301 - Disclosure - Accumulated Other Comprehensive Income (Details) link:presentationLink link:calculationLink link:definitionLink 40402 - Disclosure - Fair Value Measurements - Additional information (Details) link:presentationLink link:calculationLink link:definitionLink 40701 - Disclosure - Leases (Details) link:presentationLink link:calculationLink link:definitionLink 40801 - Disclosure - Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 41002 - Disclosure - Other Long-Term Liabilities - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 41101 - Disclosure - Stockholders' Equity (Details) link:presentationLink link:calculationLink link:definitionLink 41201 - Disclosure - Stock-Based Compensation - Employee Stock Purchase Plan (Details) link:presentationLink link:calculationLink link:definitionLink 41202 - Disclosure - Stock-Based Compensation - Employee Stock Option and Incentive Plan (Details) link:presentationLink link:calculationLink link:definitionLink 41203 - Disclosure - Stock-Based Compensation - Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 41204 - Disclosure - Stock-Based Compensation - Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 41205 - Disclosure - Stock-Based Compensation - Valuation (Details) link:presentationLink link:calculationLink link:definitionLink 41301 - Disclosure - Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 41401 - Disclosure - Collaboration Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 41504 - Disclosure - Income Taxes - Carryforwards (Details) link:presentationLink link:calculationLink link:definitionLink 41701 - Disclosure - Kolltan Acquisition (Details) link:presentationLink link:calculationLink link:definitionLink 10101 - Disclosure - Nature of Business and Overview link:presentationLink link:calculationLink link:definitionLink 10201 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 10301 - Disclosure - Accumulated Other Comprehensive Income link:presentationLink link:calculationLink link:definitionLink 10401 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 10501 - Disclosure - Marketable Securities link:presentationLink link:calculationLink link:definitionLink 10601 - Disclosure - Property and Equipment, Net link:presentationLink link:calculationLink link:definitionLink 10701 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 10801 - Disclosure - Intangible Assets link:presentationLink link:calculationLink link:definitionLink 10901 - Disclosure - Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 11001 - Disclosure - Other Long-Term Liabilities link:presentationLink link:calculationLink link:definitionLink 11101 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 11201 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 11301 - Disclosure - Revenue link:presentationLink link:calculationLink link:definitionLink 11401 - Disclosure - Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 11501 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 11601 - Disclosure - Retirement Savings Plan link:presentationLink link:calculationLink link:definitionLink 11701 - Disclosure - Kolltan Acquisition link:presentationLink link:calculationLink link:definitionLink 20202 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 30203 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 30303 - Disclosure - Accumulated Other Comprehensive Income (Tables) link:presentationLink link:calculationLink link:definitionLink 30403 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 30503 - Disclosure - Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 30603 - Disclosure - Property and Equipment, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 30703 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 30903 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 31003 - Disclosure - Other Long-Term Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 31203 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 31503 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 40101 - Disclosure - Nature of Business and Overview (Details) link:presentationLink link:calculationLink link:definitionLink 40201 - Disclosure - Summary of Significant Accounting Policies - Basis of Presentation (Details) link:presentationLink link:calculationLink link:definitionLink 40205 - Disclosure - Summary of Significant Accounting Policies - Foreign Currency Translation (Details) link:presentationLink link:calculationLink link:definitionLink 40502 - Disclosure - Marketable Securities - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 41501 - Disclosure - Income Taxes - Benefit (Provision) (Details) link:presentationLink link:calculationLink link:definitionLink 41601 - Disclosure - Retirement Savings Plan (Details) link:presentationLink link:calculationLink link:definitionLink