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  <xsd:element name="RevenueFromProductDevelopmentAndLicensingAgreements" id="cldx_RevenueFromProductDevelopmentAndLicensingAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="RevenueFromContractsAndGrants" id="cldx_RevenueFromContractsAndGrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="SignificantRevenueArrangementsDisclosureAbstract" id="cldx_SignificantRevenueArrangementsDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SignificantRevenueArrangementsDisclosureTextBlock" id="cldx_SignificantRevenueArrangementsDisclosureTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementDisclosureAbstract" id="cldx_CollaborativeArrangementDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WorkingCapital" id="cldx_WorkingCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="FiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable" id="cldx_FiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="InProcessResearchAndDevelopmentMember" id="cldx_InProcessResearchAndDevelopmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AmgenAmendmentMember" id="cldx_AmgenAmendmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CoreTechnologyMember" id="cldx_CoreTechnologyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentLenderDomain" id="cldx_DebtInstrumentLenderDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MidCapFinancialLLCMember" id="cldx_MidCapFinancialLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockIssuedByTypeOfProgramDomain" id="cldx_StockIssuedByTypeOfProgramDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ControlledEquityOfferingProgramMember" id="cldx_ControlledEquityOfferingProgramMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="GeneralElectricCapitalCorporationMember" id="cldx_GeneralElectricCapitalCorporationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassLineItems" id="cldx_FiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IntangibleAssetsGrossExcludingGoodwill" id="cldx_IntangibleAssetsGrossExcludingGoodwill" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="ScheduleOfOtherLongTermLiabilitiesTableTextBlock" id="cldx_ScheduleOfOtherLongTermLiabilitiesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DeferredIncomeFromSaleOfTaxBenefits" id="cldx_DeferredIncomeFromSaleOfTaxBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ValueOfTaxBenefitsAgreedToBeSold" id="cldx_ValueOfTaxBenefitsAgreedToBeSold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="GainLossOnSaleOfTaxBenefits" id="cldx_GainLossOnSaleOfTaxBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="PeriodForWhichBaseOfOperationsMustBeMaintained" id="cldx_PeriodForWhichBaseOfOperationsMustBeMaintained" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentLenderAxis" id="cldx_DebtInstrumentLenderAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockIssuedByTypeOfProgramAxis" id="cldx_StockIssuedByTypeOfProgramAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentInterestOnlyPeriodOfExtension" id="cldx_DebtInstrumentInterestOnlyPeriodOfExtension" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentUpFrontFeeDueUponAmendmentForExtensionOfMaturityPeriodOfDebt" id="cldx_DebtInstrumentUpFrontFeeDueUponAmendmentForExtensionOfMaturityPeriodOfDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentAdditionalFeeDueOnRepaymentForExtensionOfMaturityPeriodOfDebt" id="cldx_DebtInstrumentAdditionalFeeDueOnRepaymentForExtensionOfMaturityPeriodOfDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentPaymentFeePayableOnRepayment" id="cldx_DebtInstrumentPaymentFeePayableOnRepayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentNumberOfEqualConsecutiveMonthlyInstallments" id="cldx_DebtInstrumentNumberOfEqualConsecutiveMonthlyInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentCovenantRateOfPrepaymentPremiumInYearThree" id="cldx_DebtInstrumentCovenantRateOfPrepaymentPremiumInYearThree" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DebtInstrumentCovenantRateOfPrepaymentPremiumInYearTwo" id="cldx_DebtInstrumentCovenantRateOfPrepaymentPremiumInYearTwo" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MaximumRateOfCommissionOnSaleOfStock" id="cldx_MaximumRateOfCommissionOnSaleOfStock" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NoticePeriodForTerminationOfAgreement" id="cldx_NoticePeriodForTerminationOfAgreement" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CommonStockSharesAvailableForSale" id="cldx_CommonStockSharesAvailableForSale" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CommonStockExerciseOfFullOverAllotmentOptionToPurchaseAdditionalSharesByUnderwriter" id="cldx_CommonStockExerciseOfFullOverAllotmentOptionToPurchaseAdditionalSharesByUnderwriter" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" id="cldx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockholdersEquityTable" id="cldx_StockholdersEquityTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="StockholdersEquityLineItems" id="cldx_StockholdersEquityLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="USGovernmentAndMunicipalObligationsMember" id="cldx_USGovernmentAndMunicipalObligationsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsAmortizedCost" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsAmortizedCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesGrossUnrealizedGainAbstract" id="cldx_AvailableForSaleSecuritiesGrossUnrealizedGainAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearGrossUnrealizedGain" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearGrossUnrealizedGain" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsGrossUnrealizedGain" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsGrossUnrealizedGain" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsGrossUnrealizedGain" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsGrossUnrealizedGain" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughThreeGrossUnrealizedGain" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughThreeGrossUnrealizedGain" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesGrossUnrealizedLossesAbstract" id="cldx_AvailableForSaleSecuritiesGrossUnrealizedLossesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearGrossUnrealizedLosses" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearGrossUnrealizedLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsGrossUnrealizedLosses" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsGrossUnrealizedLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsGrossUnrealizedLosses" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsGrossUnrealizedLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughThreeGrossUnrealizedLosses" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughThreeGrossUnrealizedLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsFairValue" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughThreeYearsFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughThreeAmortizedCostBasis" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughThreeAmortizedCostBasis" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughThreeFairValue" id="cldx_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughThreeFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="AvailableForSaleSecuritiesGrossUnrealizedGainRollingMaturityAbstract" id="cldx_AvailableForSaleSecuritiesGrossUnrealizedGainRollingMaturityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AvailableForSaleSecuritiesGrossUnrealizedLossesRollingMaturityAbstract" id="cldx_AvailableForSaleSecuritiesGrossUnrealizedLossesRollingMaturityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FixedRateOfCommissionOnSaleOfStock" id="cldx_FixedRateOfCommissionOnSaleOfStock" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CommonStockIssuanceOfAdditionalSharesAggregateOfferingPrice" id="cldx_CommonStockIssuanceOfAdditionalSharesAggregateOfferingPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="CommonStockAvailableForSaleAggregateOfferingPrice" id="cldx_CommonStockAvailableForSaleAggregateOfferingPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
</xsd:schema>
</XBRL>
