Document and Entity Information Product Development and Licensing Agreements Revenue from Product Development and Licensing Agreements This element represents revenue from product development and licensing agreements. Contracts and Grants Revenue from Contracts and Grants This element represents revenue earned during the period arising from products sold or services provided under the terms of a contract. Also include revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements. SIGNIFICANT REVENUE ARRANGEMENTS Significant Revenue Arrangements Disclosure [Text Block] This element may be used to capture the complete disclosure pertaining to an entity's significant revenue contracts and arrangements. SIGNIFICANT REVENUE ARRANGEMENTS COLLABORATION AGREEMENTS Award Type [Axis] Working Capital Working capital Represents the working capital of the entity. Finite Lived and Indefinite Lived Intangible Assets by Major Class [Table] Disclosure of the carrying value of purchased amortizable finite-lived intangible assets, including disclosure of the carrying value of indefinite-lived intangible assets not subject to amortization, excluding goodwill, in total and by major class. In Process Research and Development [Member] IPR&D Represents information pertaining to in-process research and development. Amgen Amendment [Member] Amgen Amendment Represents information pertaining to an amendment to the license agreement, Amgen Amendment. Amendment Description Core Technology [Member] Core Technology Represents information pertaining to the core technology of the entity. Amendment Flag Identification of the lender, who may be a single entity (for example, a bank, pension fund or venture capital firm) or a group of entities which participate in the debt instrument. Debt Instrument Lender [Domain] MidCap Financial LLC [Member] MidCap Represents information pertaining to MidCap Financial, LLC. A group of different programs or plans under which stock of the entity is issued. Stock Issued by Type of Program [Domain] Controlled Equity Offering Program [Member] Controlled equity offering programme Represents the Controlled Equity Offering Program of the entity through which shares of common stock may be publicly offered and sold through Cantor Fitzgerald and Co. ("Cantor") in privately negotiated and/or at-the-market transactions. General Electric Capital Corporation [Member] GECC Represents information pertaining to General Electric Capital Corporation. Finite Lived and Indefinite Lived Intangible Assets by Major Class [Line Items] Intangible Assets and Goodwill Intangible Assets, Gross Excluding Goodwill Cost of total intangible assets Sum of the gross carrying amounts before accumulated amortization of all intangible assets, excluding goodwill, as of the balance sheet date. The aggregate gross carrying amount (including any previously recognized impairment charges) of a major finite-lived and indefinite lived intangible asset class. Schedule of Other Long Term Liabilities [Table Text Block] Schedule of other long-term liabilities Tabular disclosure of other long term liabilities. Deferred Income from Sale of Tax Benefits Deferred Income from Sale of Tax Benefits Represents the deferred income from the sale of tax benefit. Value of Tax Benefits Agreed to be Sold Amount of sale of New Jersey tax benefit Represents the value of tax benefits agreed to be sold by the entity during the reporting period. Gain (Loss) on Sale of Tax Benefits Gain (loss) on sale of New Jersey tax benefits Represents gain loss on sale of New Jersey tax benefits. Period for which Base of Operations Must be Maintained Period over which base of operations must be maintained Represents period for which base of operations must be maintained in New Jersey. Debt Instrument Lender [Axis] The information pertaining to the debt instrument by lender. Stock Issued by Type of Program [Axis] A categorization of various plans or programs under which stock of the entity is issued. Debt Instrument, Interest Only Period of Extension Extension of interest-only period The period of extension of interest-only period which was extended through exercise of an option for extension by the entity during the reporting period. Upfront fee due upon amendment of the Term loan Represents the upfront fee due upon amendment to extend the maturity period of the Term loan. Debt Instrument, Up front Fee Due upon Amendment for Extension of Maturity Period of Debt Current Fiscal Year End Date Debt Instrument, Additional Fee Due on Repayment for Extension of Maturity Period of Debt Additional Final Payment Fee due upon repayment of the Term Loan in full. Represents the additional fee due upon repayment of the Term Loan for the extension of the maturity period of debt. Debt Instrument, Payment Fee Payable on Repayment Original Payment Fee payable upon repayment of term loan in full Represents the original payment fee to be paid upon repayment of the Term Loan in full. Debt Instrument, Number of Equal Consecutive Monthly Installments Number of equal consecutive monthly installments Represents the number of equal consecutive monthly installments over which the loan is to be paid. Debt Instrument, Covenant Rate of Prepayment Premium in Year Three Rate of prepayment premium in year three (as a percent) Represents the percentage of prepayment premium of the Term Loan to be paid in year three. Debt Instrument, Covenant Rate of Prepayment Premium in Year Two Rate of prepayment premium in year two (as a percent) Represents the percentage of prepayment premium of Term Loan to be paid in year two. Maximum Rate of Commission on Sale of Stock Rate of commission of gross proceeds on each sale, maximum (as a percent) Represents the rate of commission on sale of stock. Notice Period for Termination of Agreement Notice period for termination of agreement Represents notice period for termination of agreement. Common Stock Shares Available For Sale Common stock available for sale (in shares) Represents the common stock available for sale. Common Stock Exercise of Full over Allotment Option to Purchase Additional Shares by Underwriter Shares issued on exercise of over-allotment option by underwriters (in shares) Represents the purchase of additional common stock. Share Based Compensation Arrangement by Share Based Payment Award Options Weighted Average Remaining Contractual Term [Abstract] Weighted Average Remaining Contractual Term (In Years) Stockholders Equity [Table] Disclosure of information pertaining to changes in stockholders' equity during the period. Document Period End Date Stockholders Equity [Line Items] Stockholders' Equity Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. Represents securities issued by US government agencies and municipal governments. U.S. government and municipal obligations US Government and Municipal Obligations [Member] Available For Sale Securities, Debt Maturities after One Through Three Years, Amortized Cost Maturing after one year through three years Amount of available-for-sale debt securities at cost, net of adjustments, maturing in the second fiscal year through the third fiscal year following the latest fiscal year. Available For Sale Securities, Gross Unrealized Gain [Abstract] Gross Unrealized Gains, fiscal maturity Available For Sale Securities, Debt Maturities within One Year Gross Unrealized Gain Maturing in one year or less Represents the gross unrealized gains on securities, at a point in time, for those securities which are expected to mature within one year of the balance sheet date, and which are categorized neither as held-to-maturity nor as trading securities. Available For Sale Securities, Debt Maturities after One Through Three Years, Gross Unrealized Gain Maturing after one year through three years Represents the gross unrealized gains on securities, at a point in time, for those securities which are expected to mature after one year and through three years from the balance sheet date, and which are categorized neither as held-to-maturity nor as trading securities. Available For Sale Securities, Debt Maturities Next Rolling Twelve Months Gross, Unrealized Gain Maturing in one year or less Represents the gross unrealized gains on securities, at a point in time, for those securities which are expected to mature within the next rolling 12 months following the latest balance sheet presented, and which are categorized neither as held-to-maturity nor as trading securities. Available For Sale Securities Debt, Maturities Rolling Year, Two Through Three Gross, Unrealized Gain Represents the gross unrealized gains on securities, at a point in time, which are for those securities which are expected to mature in the second rolling twelve months through the third rolling twelve months following the latest balance sheet presented, and which are categorized neither as held-to-maturity nor as trading securities. Maturing after one year through three years Available For Sale Securities, Gross Unrealized Losses [Abstract] Gross Unrealized Losses, fiscal maturity Maturing in one year or less Represents the gross unrealized losses on securities, at a point in time, which are expected to mature within one year of the balance sheet date, and which are categorized neither as held-to-maturity nor as trading securities. Available For Sale Securities, Debt Maturities within One Year, Gross Unrealized Losses Represents the gross unrealized losses on securities, at a point in time, which are expected to mature after one year and through three years from the balance sheet date, and which are categorized neither as held-to-maturity nor as trading securities. Available For Sale Securities, Debt Maturities after One Through Three Years, Gross Unrealized Losses Maturing after one year through three years Maturing in one year or less Represents the gross unrealized losses on securities, at a point in time, for those securities which are expected to mature within the next rolling 12 months following the latest balance sheet presented, and which are categorized neither as held-to-maturity nor as trading securities. Available For Sale Securities, Debt Maturities Next Rolling Twelve Months Gross, Unrealized Losses Maturing after one year through three years Available For Sale Securities Debt Maturities, Rolling Year Two Through Three Gross, Unrealized Losses Represents the gross unrealized losses on securities, at a point in time, which are expected to mature in the second rolling twelve months through the third rolling twelve months following the latest balance sheet presented, and which are categorized neither as held-to-maturity nor as trading securities. Available For Sale Securities, Debt Maturities after One Through Three Years, Fair Value Maturing after one year through three years Amount of available-for-sale debt securities at fair value maturing in the second fiscal year through the third fiscal year following the latest fiscal year. Amount of available-for-sale debt securities at cost, net of adjustments, maturing in the second rolling twelve months through the third rolling twelve months following the latest balance sheet presented. Adjustments include, but are not limited to, accretion, amortization, collection of cash, previous other-than-temporary impairments (OTTI) recognized in earnings (less any cumulative-effect adjustments, as defined) and fair value hedge accounting adjustments. Maturing after one year through three years Available For Sale Securities, Debt Maturities Rolling Year, Two Through Three Amortized Cost Basis Available For Sale Securities, Debt Maturities Rolling Year Two Through Three, Fair Value Amount of available-for-sale debt securities at fair value maturing in the second rolling twelve months through the third rolling twelve months following the latest balance sheet presented. Maturing after one year through three years Gross Unrealized Gains, rolling maturity Available For Sale Securities, Gross Unrealized Gain Rolling Maturity [Abstract] Available For Sale Securities, Gross Unrealized Losses Rolling Maturity [Abstract] Gross Unrealized Losses, rolling maturity Fixed Rate of Commission on Sale of Stock Fixed commission rate (as a percent) Represents the fixed commission rate expressed as a percentage of the gross sales price per share of common stock sold by the entity. Common Stock Issuance of Additional Shares Aggregate Offering Price Aggregate offering price of additional shares which the entity can issue as per amended agreement Represents the aggregate offering price of additional shares which the entity can issue as per amended agreement. Common Stock Available for Sale Aggregate Offering Price Remaining aggregate offering price available under the Cantor Amendment Represents the remaining aggregate offering price available to the entity for the issuance of common stock as per amended agreement. Available-for-sale Securities, Gross Unrealized Gains Gross Unrealized Gains Significant Accounting Policies Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Public Float Entity Registrant Name Entity Central Index Key Entity Common Stock, Shares Outstanding Accounts and Other Receivables, Net, Current Accounts and Other Receivables Document Fiscal Year Focus Document Fiscal Period Focus Document Type Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] ACCRUED EXPENSES Accounts Payable, Current Accounts Payable Accretion (Amortization) of Discounts and Premiums, Investments Amortization and Premium of Marketable Securities Accrued Liabilities, Current Accrued Expenses Accumulated Other Comprehensive Income Accumulated Other Comprehensive Income (Loss) [Member] Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated Other Comprehensive Income Additional Paid in Capital, Common Stock Additional Paid-In Capital Additional Paid-In Capital Additional Paid-in Capital [Member] Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to Reconcile Net Loss to Net Cash Used in Operating Activities: Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Share-Based Compensation Allocated Share-based Compensation Expense Total stock-based compensation expense Amortization of Intangible Assets Amortization of Acquired Intangible Assets Amortization of Intangible Assets Amortization of Debt Discount (Premium) Non-Cash Interest Expense Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Potentially dilutive common shares that have not been included in the net loss per common share calculations because the effect would have been anti-dilutive Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Anti-dilutive securities Antidilutive Securities, Name [Domain] Antidilutive Securities [Axis] Assets, Fair Value Disclosure Total financial assets at fair value Assets, Current [Abstract] Current Assets: Assets [Abstract] ASSETS Assets, Current Total Current Assets Assets. Total Assets Available-for-sale Securities, Debt Securities, Current Marketable Securities Fair Value Available-for-sale Securities, Fair Value Disclosure Marketable securities Available-for-sale Securities, Debt Maturities, Next Rolling Twelve Months, Fair Value Maturing in one year or less Available-for-sale Securities, Debt Maturities, Next Twelve Months, Fair Value Maturing in one year or less Available-for-sale Securities, Debt Maturities, Amortized Cost Basis, Fiscal Year Maturity [Abstract] Amortized Cost, fiscal maturity Available-for-sale Securities, Debt Maturities, Next Twelve Months, Amortized Cost Basis Maturing in one year or less Available-for-sale Securities, Debt Maturities, Fair Value, Fiscal Year Maturity [Abstract] Fair Value, fiscal maturity Available-for-sale Securities, Gross Unrealized Losses Gross Unrealized Losses Available-for-sale Securities, Debt Maturities, Fair Value, Rolling Maturity [Abstract] Fair Value, rolling maturity Available-for-sale Securities, Debt Maturities, Amortized Cost Basis Amortized cost Available-for-sale Securities, Debt Maturities, Next Rolling Twelve Months, Amortized Cost Basis Maturing in one year or less Available-for-sale Securities, Debt Maturities, Amortized Cost Basis, Rolling Maturity [Abstract] Amortized Cost, rolling maturity Basis of Accounting [Text Block] Basis of Presentation BUSINESS COMBINATIONS Business Combination Disclosure [Text Block] BUSINESS COMBINATIONS Cash and Cash Equivalents, at Carrying Value Cash and Cash Equivalents Cash and Cash Equivalents at Beginning of Period Cash and Cash Equivalents at End of Period Cash Acquired from Acquisition Cash Acquired in the CuraGen acquisition Cash and Cash Equivalents, Fair Value Disclosure Money market funds and cash equivalents Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Supplemental Disclosure of Non-Cash Flow Information Collaborative Arrangement Disclosure [Text Block] COLLABORATION AGREEMENTS COMMITMENTS AND CONTINGENCIES Commitments and Contingencies Disclosure [Text Block] COMMITMENTS AND CONTINGENCIES. Commitments and Contingencies Commitments and Contingent Liabilities Common Stock Common Stock [Member] Common Stock, Shares, Outstanding Common Stock, Shares Outstanding Common Stock, Value, Issued Common Stock, $.001 Par Value; 297,000,000 Shares Authorized; 60,807,350 and 44,210,636 Shares Issued and Outstanding at September 30, 2012 and December 31, 2011, respectively Common Stock, Shares, Issued Common Stock, Shares Issued Balance (in shares) Balance (in shares) Common stock issued (in shares) Common Stock, Par or Stated Value Per Share Common Stock, Par Value (in dollars per share) Common Stock, Shares Authorized Common Stock, Shares Authorized Common stock the company could issue or sell (in shares) RETIREMENT SAVINGS PLAN Comprehensive Loss COMPREHENSIVE LOSS: Comprehensive Loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive Loss Comprehensive Income (Loss) Note [Text Block] Comprehensive Loss Convertible Subordinated Debt, Current Convertible Subordinated Debt Convertible Subordinated Debt, Noncurrent Convertible Subordinated Debt Corporate Debt Securities [Member] Corporate debt securities Costs and Expenses [Abstract] OPERATING EXPENSE: Costs and Expenses Total Operating Expense Debt Instrument, Description of Variable Rate Basis Basis of interest rate Debt Instrument [Line Items] Term Loan Schedule of Long-term Debt Instruments [Table] Term Loan Debt Instrument, Basis Spread on Variable Rate Interest rate margin (as a percent) Debt Instrument, Increase, Additional Borrowings Amount borrowed Debt Instrument, Interest Rate, Stated Percentage Fixed annual interest rate (as a percent) Deferred Finance Costs, Net Capitalized deferred financing costs Deferred Rent Credit Deferred Rent Deferred Revenue, Noncurrent Deferred Revenue Deferred Revenue, Current Current Portion of Deferred Revenue Deferred Tax Liabilities, Net Net Deferred Tax Liability Depreciation, Depletion and Amortization Depreciation and Amortization Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock-Based Compensation Stock-Based Compensation Earnings Per Share, Basic and Diluted Basic and Diluted Net Loss Per Common Share (Note 3) (in dollars per share) Earnings Per Share [Text Block] Net Loss Per Share Net Loss Per Share Effect of Exchange Rate on Cash and Cash Equivalents, Continuing Operations Effect of Exchange Rate Changes on Cash and Cash Equivalents Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] Valuation and Expenses Information Employee Service Share-based Compensation, Allocation of Recognized Period Costs, Report Line [Domain] Equity Component [Domain] Estimate of Fair Value, Fair Value Disclosure [Member] Fair value Measurement Frequency [Axis] Fair Value, Hierarchy [Axis] Fair Value, Measurements, Recurring [Member] Fair Value Measurements Fair Value, Measurement Frequency [Domain] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value, Measurements, Fair Value Hierarchy [Domain] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair value measurements Fair Value Measurements Fair Value Disclosures [Text Block] Fair Value Measurements Fair Value, Assets Measured on Recurring Basis [Table Text Block] Schedule of financial assets subject to fair value measurements Fair Value, Inputs, Level 3 [Member] Level 3 Fair Value, Inputs, Level 1 [Member] Level 1 Fair Value, Inputs, Level 2 [Member] Level 2 Finite-Lived Intangible Asset, Useful Life Estimated Life Finite-Lived Intangible Assets, Major Class Name [Domain] Finite-Lived Intangible Assets, Gross Cost Finite-Lived Intangible Assets by Major Class [Axis] Finite-Lived Intangible Assets, Accumulated Amortization Accumulated Amortization Finite-Lived Intangible Assets, Net [Abstract] Finite-lived intangible asset Finite-Lived Intangible Assets, Net Net Gain (Loss) on Disposition of Assets Gain on Sale of Assets Gain (Loss) on Sale of Property Plant Equipment Gain on Sale or Disposal of Assets General and Administrative Expense General and Administrative General and Administrative Expense [Member] General and administrative Goodwill Goodwill Goodwill and Intangible Assets Disclosure [Text Block] Intangible Assets and Goodwill Intangible Assets and Goodwill Income (Loss) from Continuing Operations before Income Taxes, Extraordinary Items, Noncontrolling Interest Net Loss Before Income Taxes CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPRENHENSIVE LOSS Income Tax Disclosure [Text Block] Income Taxes Income Taxes Income Tax Expense (Benefit) Income Tax Benefit Increase (Decrease) in Deferred Revenue Deferred Revenue Increase (Decrease) in Accounts and Other Receivables Accounts and Other Receivables Increase (Decrease) in Accounts Payable and Accrued Liabilities Accounts Payable and Accrued Expenses Increase (Decrease) in Operating Capital [Abstract] Changes in Operating Assets and Liabilities: Increase (Decrease) in Prepaid Expense and Other Assets Prepaid and Other Current Assets Increase (Decrease) in Other Operating Assets Other Assets Increase (Decrease) in Other Operating Liabilities Other Liabilities Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Indefinite-Lived Intangible Assets (Excluding Goodwill) Indefinite-lived intangible assets Indefinite-lived Intangible Assets by Major Class [Axis] Indefinite-lived Intangible Assets, Major Class Name [Domain] Indefinite-Lived Intangible Assets (Excluding Goodwill) [Abstract] Indefinite-lived intangible assets: Intangible Assets, Net (Excluding Goodwill) [Abstract] Total Intangible Assets Intangible Assets, Net (Excluding Goodwill) Intangible Assets, Net Net total intangible assets Interest Expense Interest Expense Interest Expense, Long-term Debt Interest expense on the term loan Cash Paid for Interest Interest Paid Investments and Cash Cash, cash equivalents and marketable securities Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Marketable Securities Marketable Securities Long-term Debt, Type [Domain] Long-term Debt, Type [Axis] Liabilities, Current Total Current Liabilities Liabilities, Current [Abstract] Current Liabilities: Liabilities Total Liabilities Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities and Equity Total Liabilities and Stockholders' Equity Loans Payable Loan Payable Long-term Debt [Text Block] Term Loan Major Types of Debt and Equity Securities [Axis] Major Types of Debt and Equity Securities [Domain] Marketable Securities, Gain (Loss) Realized (Gain) Loss on Sales and Maturities of Marketable Securities Maximum [Member] Maximum Minimum [Member] Minimum Cash Flows from Financing Activities: Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Net Cash Used in Operating Activities Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operations Cash Flows from Operating Activities: Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Net Cash Provided by (Used in) Continuing Operations Net Increase (Decrease) in Cash and Cash Equivalents Net Cash Used in Investing Activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net Loss Net Loss Net Income (Loss) Available to Common Stockholders, Basic Net Cash Provided by Financing Activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations Cash Flows from Investing Activities: Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Nonoperating Income (Expense) Investment and Other Income, Net Number of States in which Entity Operates Number of states in which the entity primarily operates or has operated and has income tax nexus Operating Income (Loss) Operating Loss Basis of Presentation Other Long-Term Liabilities Other Assets, Noncurrent Other Assets Other Sundry Liabilities Other Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Unrealized Gain (Loss) on Marketable Securities Other Liabilities, Current Current Portion of Long-Term Liabilities Less Current Portion Other Liabilities, Noncurrent Other Long-Term Liabilities Long-Term Portion Non-Cash Tax Benefit Other Noncash Income Tax Expense Other Liabilities Disclosure [Text Block] Other Long-Term Liabilities Other Liabilities Total Other Comprehensive (Loss) Income: Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Foreign Currency Translation Adjustments ACCRUED EXPENSES Payments to Acquire Property, Plant, and Equipment Acquisition of Property and Equipment Payments to Acquire Marketable Securities Purchases of Marketable Securities RETIREMENT SAVINGS PLAN Pension and Other Postretirement Benefits Disclosure [Text Block] Preferred Stock, Value, Issued Convertible Preferred Stock, $.01 Par Value; 3,000,000 Shares Authorized; No Shares Issued and Outstanding at September 30, 2012 and December 31, 2011 Preferred Stock, Shares Authorized Convertible Preferred Stock, Shares Authorized Preferred Stock, Shares Issued Convertible Preferred Stock, Shares Issued Preferred Stock, Par or Stated Value Per Share Convertible Preferred Stock, Par Value (in dollars per share) Preferred Stock, Shares Outstanding Convertible Preferred Stock, Shares Outstanding Prepaid Expense and Other Assets, Current Prepaid and Other Current Assets Proceeds from Issuance of Long-term Debt (Payments) Issuance of Term Loan Proceeds from Issuance of Common Stock Net Proceeds from Stock Issuances Net proceeds from issuance of common stock Proceeds from Sale and Maturity of Marketable Securities Sales and Maturities of Marketable Securities Proceeds from Sale of Productive Assets Proceeds from Sale or Disposal of Assets PROPERTY AND EQUIPMENT, NET Property, Plant and Equipment, Net Property and Equipment, Net PROPERTY AND EQUIPMENT, NET Property, Plant and Equipment Disclosure [Text Block] SELECTED QUARTERLY FINANCIAL DATA (Unaudited) Quarterly Financial Information [Text Block] SELECTED QUARTERLY FINANCIAL DATA (Unaudited) Range [Axis] Range [Domain] Repayments of Subordinated Debt Related Party Loan Due to Medarex Repayments of Other Long-term Debt Payments of Other Liabilities Payment of Convertible Subordinated Debt Repayments of Convertible Debt Research and Development Expense Research and Development Research and Development Expense [Member] Research and development Restricted Stock [Member] Restricted stock Retained Earnings (Accumulated Deficit) Accumulated Deficit Accumulated Deficit Retained Earnings [Member] Revenues Total Revenue Revenues [Abstract] REVENUE: Royalty Expense Royalty Royalty Revenue Product Royalties Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Expected option term Options Exercisable at the end of the period Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Options vested and expected to vest at the end of the period Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Options outstanding at the beginning of the period Options outstanding at the end of the period Scenario, Unspecified [Domain] Schedule of Nonvested Share Activity [Table Text Block] Schedule of restricted stock activity Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] Schedule of stock option activity Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of assumptions used for the fair values of employee stock options granted Schedule of Available-for-sale Securities [Table] Schedule of Intangible Assets and Goodwill [Table Text Block] Schedule of intangible assets, net of accumulated amortization, and goodwill Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of potentially dilutive common shares excluded from the net loss per common share calculations Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Available-for-sale Securities [Line Items] Marketable Securities Schedule of Available-for-sale Securities Reconciliation [Table Text Block] Schedule of marketable securities Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs, by Report Line [Axis] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table] Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] Schedule of stock-based compensation expense Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Term Loan, less Current Portion Secured Long-term Debt, Noncurrent Current Portion of Term Loan Secured Debt, Current Secured Debt [Member] Term Loan Secured Debt Term loan Amount owed under the term loan Share-based Compensation Arrangement by Share-based Payment Award, Additional General Disclosures [Abstract] Additional information on options Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Shares Share-based Compensation Stock-Based Compensation Expense Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Canceled (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Granted (in dollars per share) Expected stock price volatility, maximum (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Canceled (in shares) Expected stock price volatility, minimum (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum Outstanding and unvested at the end of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Outstanding and unvested at the beginning of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward] Weighted Average Exercise Price Per Share Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum Risk-free interest rate, maximum (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Roll Forward] Weighted Average Grant Date Fair Value (per share) Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Stock-Based Compensation Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Outstanding and unvested at the beginning of the period (in shares) Outstanding and unvested at the end of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Canceled (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Granted (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum Risk-free interest rate, minimum (as a percent) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Exercised (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Risk-free interest rate (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Expected stock price volatility (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price Options Exercisable at the end of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Expected dividend yield (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Vested (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Weighted average grant-date fair value (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Options exercisable at the end of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Shares Available for Grant under the 2008 Plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Shares Maximum shares of common stock to be issued for grants (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract] Assumptions used for fair values of employee stock options granted Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Canceled (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Options vested and expected to vest at the end of the period (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Options outstanding at the beginning of the period (in dollars per share) Options outstanding at the end of the period (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Options outstanding at the beginning of the period (in shares) Options outstanding at the end of the period (in shares) Award Type [Domain] Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Options vested and expected to vest at the end of the period (in dollars per share) Significant Accounting Policies Significant Accounting Policies [Text Block] Statement [Table] Scenario [Axis] Statement [Line Items] Statement CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS Equity Components [Axis] CONDENSED CONSOLIDATED BALANCE SHEETS Stock Issued During Period, Shares, Period Increase (Decrease) Stock Issued During Period, Shares, Period Increase (Decrease) Stock Issued During Period, Shares, Acquisitions Shares Issued in Connection with the CuraGen acquisition (in shares) Stock Options [Member] Stock options Stock Issued During Period, Value, Acquisitions Shares Issued in Connection with the CuraGen acquisition Stock Issued During Period, Value, New Issues Shares Issued in Underwritten Offering Net proceeds from sale of stock in an underwritten public offering Stock Granted During Period, Value, Share-based Compensation, Net of Forfeitures Shares Issued to Executive Officers Shares Issued in Connection with Cantor Agreement (in shares) Stock Issued During Period, Shares, Other Shares Issued in Underwritten Offering (in shares) Stock Issued During Period, Shares, New Issues Common stock in an underwritten public offering issued (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercised (in shares) Stock Issued During Period, Value, Employee Stock Purchase Plan Shares Issued under Stock Option and Employee Stock Purchase Plans Shares Issued in Connection with Cantor Agreement Stock Issued During Period, Value, Other Stock Issued During Period, Shares, Employee Stock Purchase Plans Shares Issued under Stock Option and Employee Stock Purchase Plans (in shares) Stockholders' Equity: Stockholders' Equity Attributable to Parent [Abstract] Stockholders' Equity Attributable to Parent Total Stockholders' Equity Balance Balance Balance Stockholders' Equity Stockholders' Equity Note Disclosure [Text Block] Stockholders' Equity Stockholders' Equity, Period Increase (Decrease) Stockholders' Equity, Period Increase (Decrease) Supplemental Disclosure of Cash Flow Information Supplemental Cash Flow Information [Abstract] Shares Used in Calculating Basic and Diluted Net Loss per Share (Note 3) (in shares) Weighted Average Number of Shares Outstanding, Basic and Diluted